Organoselenium Compounds in Biology and Medicine

Organoselenium Compounds in Biology and Medicine

Synthesis, Biological and Therapeutic Treatments

Singh, H. B. (Indian Institute of Technology Bombay, India); Wessjohan, Ludger A. (Leibniz Institute of Plant Biochemistry, Germany); Priyadarsini, K. Indira; Lippolis, Vito (Complesso Universitario di Monseratto); Jain, Vimal Kumar (Bhabha Atomic Research Centre, India); Jain, Vimal Kumar (Bhabha Atomic Research Centre, India); Iwaoka, M. (Tokai University, Japan); Ando, Hiromune (Gifu University, Japan); Santi, Claudio (University of Perugia, Italy); Wirth, Thomas (Cardiff University)

Royal Society of Chemistry

10/2017

457

Dura

Inglês

9781788010290

15 a 20 dias

This book discusses organoselenium chemistry and biology in the context of its therapeutic potential, taking the reader through synthetic techniques, bioactivity and therapeutic applications
An overview of organoselenium chemistry: From fundamentals to Synthesis; Looking Beyond the traditional Idea of Glutathione Peroxidase Mimics as Antioxidants; Synthesis of organoselenium compounds with potential biological activities; The Relevant Chemistry of Imidazoline-2-selone Donors with potential Biological Applications; Organoselenium cations: Structures, reactivity and applications; Organoselenium flurophores for probing ROS and heavy metals; Non-bonded selenium...heteroatom interactions in selenoenzymeglutathioneperoxidase (GPx) and mimics; Carbohydrate-derived Organoselenium Compounds: Synthesis and Application in the Structural Analysis of Biomolecules; Reaction of Selenium compounds with reactive oxygen species and the controlof oxidative stress; Reactive selenium species: Redox modulation, antioxidant, antimicrobial and anticancer activities; Ebselen and thioredoxin systems in human health, disease and therapeutic potential; History and development of selenium based radioprotectors: Distinction between inorganic vs. organic forms; Toxicology and anticancer activity of synthetic organoselenium compounds; Metabolism of selenium/selenocystine and their roles in the prevention and treatment of human cancer; Organoselenium compounds as cancer therapeutic agents; Cancer prevention by different forms of selenium
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